研究人員全面系統(tǒng)檢索了MEDLINE和 EMBASE以及自1980年1月至2014年11月期間發(fā)表的主要肝臟會議的會議記錄。研究人員進行成對
meta-分析和Bayesian框架分析。研究終納入了17項臨床試驗，包括2764例乙型肝炎表面抗原陽性母親所生的新生兒(LdT vs對照組：7項試驗;LAM
vs 對照組：8項試驗;LdT vs LAM：2項試驗)。研究中并未納入替諾福韋(TDF)或恩替卡韋(ETV)的臨床試驗。研究結(jié)果顯示：
成對meta分析顯示，相比于安慰劑組，替比夫定(HR，0.12，95% CI ,0.04-0.37;I2 = 0%)和拉米夫定 (HR,
0.40，95%CI 0.24-0.65;I2 =
0%)可更有效地降低高病毒血癥HBeAg陽性慢乙肝中國患者的HBV垂直傳播。針對HBeAg陽性個體研究的敏感性分析顯示了相似的結(jié)果。
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